| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Di and tripeptides from marine sources can target adipogenic process and contribute to decrease adipocyte number and functions
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| Autores: |
Ben Henda, Yesmine
Laamari, Mariem
Lanneluc, Isabelle
Travers, Marie-agnes
Agogue, Helene
Arnaudin, Ingrid
Bridiau, Nicolas
Maugard, Thierry
Piot, Jean-marie
Sannier, Frederic
Bordenave-juchereau, Stephanie
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| Data: |
2015-08
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| Ano: |
2015
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| Palavras-chave: |
Bioactive peptides
Obesity
Human white pre-adipocytes'
Proliferation
Differentiation
Adipocyte differentiation markers
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| Resumo: |
The effect of 11 marine-derived cryptides was investigated on proliferation, differentiation and maturation of human white pre-adipocytes (HWP). They were all formerly identified as potent Angiotensin-Converting-Enzyme inhibitors.Val-Trp (VW),Val-Tyr (VY), Lys-Tyr (KY), Lys-Trp (KW), Ile-Tyr (IY), Ala-Pro (AP),Val-Ile-Tyr (VIY), Leu-Lys-Pro (LKP), Gly-Pro-Leu (GPL), Ala-Lys-Lys (AKK) and Val-Ala-Pro (VAP) were previously found in fish products and coproducts as well as other marine resources like wakame. Treatment with AP, VAP and AKK greatly affected viability of HWP during the proliferation period while KW and VW treatment reduced the number of viable cells during the differentiation stage. A GPL and IY incubation during the differentiation stage allowed the decrease of their final lipid content, of the GPDH activity and of the mRNA level of adipocyte markers (aP2, GLUT4, LPL and AGT). Moreover, a down regulation of both PPARγ and C/EBPα expression, two key regulators of adipogenesis,was observed.These findings indicate that small bioactive peptides from marine protein hydrolysates can target adipogenesis and thus could regulate energy metabolism disorders
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00269/38014/36308.pdf
DOI:10.1016/j.jff.2015.04.050
http://archimer.ifremer.fr/doc/00269/38014/
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| Editor: |
Elsevier Science Bv
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| Formato: |
application/pdf
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| Fonte: |
Journal Of Functional Foods (1756-4646) (Elsevier Science Bv), 2015-08 , Vol. 17 , P. 1-10
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| Direitos: |
2015 Elsevier Ltd. All rights reserved
info:eu-repo/semantics/openAccess
restricted use
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